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Structure Therapeutics (NASDAQ: GPCR) initiated a Phase 1 clinical trial for its oral obesity drug ACCG-2671 on December 17, 2025, causing its stock to climb 3.92%.
On December 11, 2025, Structure Therapeutics Inc. (NASDAQ: GPCR) closed an upsized public offering, raising gross proceeds of approximately $747.5 million to fund its metabolic disease pipeline.
A new front has opened in the multi-billion-dollar obesity drug market. Smaller biotechs are posting strong clinical data for oral treatments, directly challenging the injectable-led duopoly of Eli Lilly and Novo Nordisk and signaling a broader, more competitive platform war.
Zealand Pharma announced its "Metabolic Frontier 2030" strategy and a potential $2.5B partnership with OTR Therapeutics. The move aims to challenge leaders Novo Nordisk and Eli Lilly in the rapidly fragmenting, $150B weight-loss drug market, despite a 29% year-to-date stock decline.
The surging market for GLP-1 obesity drugs is creating a significant downstream opportunity for key suppliers of injectable delivery systems. West Pharmaceutical is strategically positioned to capitalize on this trend through its portfolio of High-Value Product (HVP) components, though it faces broader manufacturing headwinds.
Novo Nordisk's stock has fallen over 58% in the past year as its dominance in the GLP-1 weight-loss market is challenged by intense competition, slowing growth, and looming patent expirations. While the company defends its position with strategic acquisitions and pipeline diversification, analyst sentiment is sharply divided, reflecting a fundamental debate over its valuation and future prospects.
A frenzy of positive clinical data from smaller biotechs is challenging the dominance of Eli Lilly and Novo Nordisk in the lucrative obesity drug market. New mechanisms focusing on muscle preservation and oral delivery are driving significant stock rallies and reshaping investor expectations.